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      探索發現 · 學術講座

      Biomimetic materials for biomedical engineering studies and applications


      奚望,2004年本科畢業于中國科學技術大學高分子材料與工程系,2009年于牛津大學化學系獲得博士學位,之后在德國萊布尼茨固態物理和材料研究所和馬克斯-普朗克智能系統研究所和新加坡國立大學從事研究工作。現為法國國家科學研究中心“瑪麗居里學者”(Marie Curie Fellow),主要研究領域包括微納材料加工制作,可穿戴傳感器,微流控器件和組織工程學,在Nature Review Materials, Nature Communications, PNAS, Advanced Materials, Nano Letters, ACS Nano等學術期刊上以第一作者或者通訊作者發表SCI論文26篇,同時獲得授權國際專利2項。奚望博士的研究在同行中產生一定的影響力獲得多次國際獎勵和稱號,包括法國教育署的“卓越學者”(Prestige Fellow)和歐盟研究理事會的“瑪麗居里學者”(Marie Curie Fellow)。







      Communities of epithelial cells communicate through intercellular interactions, allowing them to coordinate their motility, which plays a key role in homeostasis, morphogenesis and cancer metastasis. Each cell in the epithelium is a constitutive energy-consuming agent, which can generate forces and interact with other cells through cell-cell junctions. Forces applied through external stimuli or endogenous cellular events are balanced by the cells within the epithelium, resulting in the adjustment of internal tissue contractile stresses and tissue reorganization. Materials science and microengineering techniques can be combined to create controllable environments to study epithelial movement and mechanics. By modulating the cell-material interface and by applying principles of active matter, key aspects of epithelial dynamics and mechanosensing mechanisms can be investigated. In this talk, we will discuss epithelial tissues as active materials with particular rheological properties and active behaviours at different length scales. We highlight 2D and 3D materials for the study of epithelial dynamics and summarize key methods for the probing of epithelial mechanics. Tissue responses to mechanical stimuli are examined from the molecular level to the tissue level, and the effects of the shape, architecture and stiffness of the microenvironment are discussed.